miRNA vs. siRNA: Key Differences, Mechanisms, and Therapeutic Uses
miRNA and siRNA are both small, non-coding RNA molecules that silence genes, but they are not interchangeable. miRNA is endogenous, fine-tunes dozens of genes at once, and binds imperfectly to target mRNA. siRNA is usually synthetic, knocks down a single gene with perfect complementarity, and triggers mRNA cleavage. In the clinic, headlines trumpet “RNA drug…