O Acylation vs N Acylation: Key Differences Explained
O Acylation tags an acyl group to the oxygen of an alcohol or phenol; N Acylation pins that same carbonyl onto the nitrogen of an amine or amide. Same reagent, different address on the molecule. Lab mates mix them up because “acylation” sounds like one reaction. In med-chem meetings, someone says “we acylated the scaffold”…